Hauv kev kho mob niaj hnub thiab kws kho mob, qee cov kev tshawb nrhiav tau tshwm sim tsis tu ncua. Txhua yam yog ua los mus piv rau kev kho mob ntawm tej yam kab mob. Ib qho ntawm cov paj ntaub ntau tshaj plaws yog monoclonal antibodies. Feem ntau cov tshuaj tiv thaiv los ntawm lub cev yog polyclonal. Cias muab, lawv tsim los mus sib ntaus nrog cov sib txawv antigens, uas ho txo cov hauj lwm zoo ntawm kev kho mob. Monoclonal antibodies tswj lub hom phiaj, uas yuav tau txais qhov txiaj ntsim zoo tshaj plaws ntawm qhov ua tau zoo.
Ntsiab cai ntawm kev kho mob nrog monoclonal antibodies
Hnub, monoclonal tshuaj tiv thaiv yog siv rau kev tsom xam lossis qhov kev sib txuas lus. Raws li cov kev kuaj pom, qhov no qhia tau hais tias qhov kev kho tau zoo tshaj plaws.
Monoclonal antibodies yog cov tshuaj tiv thaiv uas tsim los ntawm ib qho cellular clone. Ntawd yog, lawv txhua tus muaj tsuas yog ib tus thawj ntawm tes. Monoclonal antibodies yog siv rau:
- mob plab ;
- rheumatoid kev mob caj dab;
- psoriasis;
- ntau yam sclerosis .
Lawv tuaj yeem tiv thaiv txawm tias cov feem ntau ntawm cov mob oncology.
Lub hauv paus ntawm kev txiav txim ntawm monoclonal antibodies yog yooj yim heev: lawv paub txog cov antigens thiab muab xa mus rau lawv. Tsaug rau qhov no, lub cev tiv thaiv kab mob sai sai pom qhov teeb meem thiab pib tua nws. Qhov tseeb, monoclonal antibodies cia lub cev tshem cov antigens ntawm nws tus kheej. Lwm qhov zoo ntawm MCA yog tias lawv tsuas yog cuam tshuam kev hloov cov qe ntshav uas tsis tsim kev puas tsuaj rau kev noj qab haus huv.
Monoclonal antibodies nyob rau hauv oncology
Rau ntau tus neeg mob uas muaj kev mob oncology, tshuaj xws li monoclonal antibodies tau ua ib txoj kev cia siab rau kev xa rov qab. Ib feem ntau ntawm cov neeg mob uas muaj cov tsos mob loj heev thiab kev poob siab vim tias tom qab kev kho mob tau txais kev pom zoo.
Zoo ntawm ICA yog pom tseeb:
- Txuas ntxiv rau cov kabmob kheesxaws hlwb, monoclonal antibodies tsis tsuas yog ua rau lawv pom ntau, tabsis kuj tsis muaj zog. Thiab nrog txoj kev kho tau yooj yim kho hlwb, lub cev yooj yim dua mus tua.
- Cov monoclonal antibodies uas tau pom tias lawv lub hom phiaj pab thaiv cov neeg txais kab mob ntawm kev loj hlob. Ua tsaug rau qhov kev kho mob ntawm oncology no heev yooj yim.
- Cov tshuaj tua kab mob tau txais hauv qhov kev kuaj, qhov uas lawv tau sib xyaw ua ke nrog me me ntawm cov khoom cua. Kev xa cov khoom no los ntawm lub cev, MCA xa lawv raws nraim rau lub pob, qhov uas lawv ua.
Kev kho mob cancer nrog monoclonal tshuaj yuav muab piv nrog radiotherapy. Tab sis tsis zoo li yav tas los, ICA ua milder. Lawv lub hom phiaj ua rau nws siv tau tsawg dua cov xov tooj cua.
Cov tshuaj muaj monoclonal antibodies
Dua li ntawm qhov tseeb tias ICA tau tsim tsis ntev dhau los, qhov ntau ntawm kev npaj uas muaj lawv twb zoo zoo nkauj heev. Cov tshuaj tshiab tuaj yeem tshwm sim.
Feem ntau cov monoclonal antibodies uas tau siv rau psoriasis, ntau yam sclerosis, cancer, rheumatoid mob caj dab, colitis zoo li no:
- Alemtuzumab;
- Alefacept;
- Daclusimab;
- Okrelizumab;
- Ustenkinumab;
- Basiliximab;
- Ofatumumab;
- Epratuzumab;
- Clenoliximab;
- Bevacizumab;
- Trastuzumab;
- Adalimumab;
- Enbrel;
- Infliximab thiab lwm tus.
Ntawm chav kawm, monoclonal antibodies, zoo li ntau lwm yam tshuaj, muaj peev xwm muaj kev phiv. Feem ntau, cov neeg mob tom qab siv ICA yws ntawm qhov kev tsis haum ntawm kev fab tshuaj: khaus, pob khaus. Feem ntau, kev kho mob yog los ntawm xeev siab, ntuav, los yog tsis meej hauv plab hnyuv.