Calcium antagonists yog hu ua pab pawg me ntawm cov tshuaj uas muaj peev xwm ua kom tsis muaj tsheb thauj mus los ntawm cov khoom no los ntawm kev tshwj xeeb rau hauv cov leeg hlwb. Cov kws kho mob plawv siv cov tshuaj no heev. Lawv pab kho cov kab mob sib txawv. Vim tias lawv cov nyhuv ntxim ntxub, qhov kev tsim cov tshuaj calcium nkag yog pom tias yog ib qho tseem ceeb tshaj plaws ntawm kev lag luam hauv lub xyoo pua nees nkaum.
Lub mechanism ntawm kev txiav txim ntawm calcium antagonists
Calcium ions tseem ceeb heev rau lub cev. Lawv koom nrog ntau lub neej. Kom sai raws li cov khoom nkag mus rau lub hlwb, cov txheej txheem yog qhib kom ua rau, vim yog lub cev muaj zog ntawm kev ua haujlwm ntawm lub cev. Yog calcium ions ua dhau los, cov tshuaj metabolism hauv cell tau loj heev. Tiv thaiv no tom qab, qhov xav tau cov ntaub so ntswg hauv cov pa oxygen thiab cov khoom pabcuam yuav nce. Thiab qhov no, tig mus, ua rau kev pauv hloov.
Antagonists ntawm cov poov hlau cov kua ntsev txo lawv cov concentration thiab tsis txhob cia cov khoom kom nkag mus ntawm qhov chaw seem rau hauv lub hlwb. Lawv kuj txhawb vasodilation thiab txo cov ntshav siab.
Thaum twg yog calcium antagonists?
- Nrog vasospastic angina, calcium channel blockers yog zoo heev. Raws li kev xyaum qhia, qaug dab peg lawv tiv thaiv kom zoo dua li lwm yam.
- Antagonists sai sai txo lub siab, yog li tsis muaj lawv nws yog nyuaj rau tiv nrog crises nyob rau hauv kub siab .
- Lub plawv tsis ua haujlwm yog qhov teebmeem ntawm qhov teeb meem. Cov tshuaj thaiv cov tshuaj calcium uas yuav kho tau nws cov tshuaj, tab sis lawv tsis pab txhua tus.
- Kev npaj-antagonists ntawm calcium ions tsis muaj pov thawj nyob rau hauv tawm tsam tawm tsam kev mob ntsws rov qab ntawm mob myocardial infarctions. Kev tiv thaiv qaug dab peg tsis zoo heev, tab sis nyob rau lub sij hawm tom qab teeb meem nws zoo heev.
- Cov neeg mob uas tsis ruaj tsis khaus angina pectoris yog cov tshuaj calcium blockers feem ntau nrog metoprolol. Txoj kev sib txuam no yog ntau qhov txiaj ntsig ntawm lub cev.
Daim ntawv teev cov tshuaj calcium antagonist tshuaj
Cov kws kho mob tshwj xeeb qhia txog peb pawg ntawm cov yeeb tshuaj:
- Cov derivatives ntawm phenylalkylamines "pib" nrog Verapamil. Cov tshuaj ntawm pawg neeg no tuaj yeem cuam tshuam rau cov nqaij ntawm lub plawv thiab cov hlab ntsha. Lawv tsis xav ua kom tau nrog cov beta-blockers, vim hais tias qhov no tus myocardium yuav tau txais cov nyhuv ob, vim yog qhov ua rau cov khoom siv atrioventricular yuav raug ua txhaum.
- Thawj lub txiaj ntsig ntawm dihydropyridine yog Nifedipine. Lub ntsiab tseem ceeb ntawm kev siv tshuaj yog vasodilator kev txiav txim. Daim ntawv teev cov tshuaj calcium antagonists ntawm pawg thib ob yog tsi ntsees los ntawm kev ua. Ua ntej ntawm tag nrho cov, tshuaj noj rau cov hlab ntsha coronary. Thiab lawv yuav luag tsis muaj kev phiv.
- Cov pab pawg tom kawg muaj xws li benzothiazepine derivatives, uas tam sim no tsuas yog sawv cev los ntawm Diltiazem.
Muaj lwm yam tshuaj-calcium antagonists. Cov feem ntau nto moo thiab zoo yog:
- Finoptin;
- Baypress;
- Lomir;
- Clentiazem;
- Gallopamil;
- Felodipine;
- Nitrendipine;
- Lacidipine;
- Lercanidipine;
- Isradipine;
- Corinfar;
- Cordaflex;
- Osmo-Adalat;
- Kordafen;
- Amlotop;
- Norvasc;
- Plandil;
- Stamlo;
- Dilren;
- Diles;
- Altiazem.
Tag nrho cov calcium antagonists tsis pom zoo kom tau muab cov tshuaj tua kab mob hauv, lawv yuav tsum tau siv cov kab mob xwb. Cov tshuaj yuav ua rau cov leeg tsis sib haum xeeb uas tswj tsis tau, uas, raws li txoj cai, muaj zog thiab ntev heev. Uas ua rau kis tau tus mob ntawm cov hlab ntsha thiab tuag ntawm cov nqaij.