Prokinetics yog cov tshuaj uas muaj rau cov neeg mob plab hnyuv loj. Ib qho tseeb qhov tseeb txuas nrog lawv. Cov npe ntawm cov tshuaj prokinetic, uas yuav tsum lees paub los ntawm tag nrho cov kws kho mob gastroenterologists, tsis muaj nyob. Cov kws tshwj xeeb txawv ntau tus txhais tau li ib daim ntawv teev npe. Dab tsi yog qhov prokinetics?
Prokinetic antagonists ntawm dopamine receptors
Cov nyhuv ntawm prokinetic antagonists yog raws li qhov tseeb tias lawv sai khoov rau D2-dopamine receptors thiab txo txo lawv cov lus teb rau cov kev qhia ntawm tib neeg lub cev. Ua tsaug rau qhov no lawv tuaj yeem pab qhib lub cev muaj zog ntawm lub plab, nrog rau kev txhawb nqa tshuaj tiv thaiv. Cov npe ntawm cov tshuaj xws prokinetic muaj xws li:
- Bromopride;
- Domperidone;
- Metoclopramide;
- Dimetramipid.
Feem ntau, tag nrho cov ntawm lawv yog siv rau kev kho mob ntawm gastrointestinal txoj cai Domperidone, nyob rau hauv kev phem ntawm qhov tseeb hais tias nws yog ib tug prokinetic ntawm ob tiam. Qhov no yog vim muaj qhov tseeb tias nws tsis muaj kev phom sij tseem ceeb.
Qee cov kws txawj hais txog qhov pab pawg neeg ntawm antagonists thiab Itopride. Tab sis officially no yog tsis pom zoo, vim nws muaj ib qho kev cuam tshuam cov kab mob hauv acetylcholine. Tsis tas li ntawd nyob rau hauv pab pawg neeg ntawm prokinetics yog npaj ntawm thawj tiam ntawm Reglan thiab Cerukal. Thiab tag nrho vim hais tias ntawm lawv cov khoom muaj nyob hauv yog metoclopramide. Hauv qab qee kis, yuav ua tau rau tachycardia, tinnitus, nkees nkees thiab kiv taub hau.
Prokinetic antagonists yog siv thaum:
- achalasia ntawm txoj hlab pas ;
- roog ntawm plab lossis duodenum;
- txiav cov hnyuv, uas tshwm sim tom qab ua haujlwm;
- flatulence;
- kev kho mob ntawm tus kab mob gastroesophageal reflux;
- muaj zog dyspepsia;
- teeb meem loj heev ntawm bile ducts.
Feem ntau, cov tshuaj uas yog ib feem ntawm pawg no tuaj yeem muab rau cov kab mob hauv lub raum thiab lub siab, ntuav thiab xeev siab los ntawm cov kab mob sib kis, los yog kev siv hluav taws xob. Lawv feem ntau siv los tiv thaiv ntuav ua ntej endoscopy los yog ntau yam kev tshawb fawb radiopaque.
Prokinetics-stimulants ntawm plab hnyuv peristalsis
Cov neeg paub ntau pawg ntawm pawg neeg no yog cov kev npaj kev tuav cov npe ntawm Coordax thiab Mozapride. Lawv zoo sib xws nyob rau hauv txoj kev ntawm kev nqis tes ua. Lawv txawv tsuas yog tias Mozapride tau ua haujlwm tsis muaj teebmeem rau kev ua haujlwm ntawm cov kab mob qaub ncaug, thiab qhov no ho txo qhov kev pheej hmoo ntawm kev mob plawv dhia.
Pawg no kuj muaj cov tshuaj xws li:
- Aceclidine;
- Tshaj plaws;
- Physiostigmine;
- Pyridostigmine bromide;
- Galantamine;
- Neostigmine monosulfate.
Prokinetics-agonists ntawm motilin receptors
Cov tshuaj prokinetic kuj muaj xws li cov tshuaj uas khi rau cov txauj rau cov pob txha mos (ib yam tshuaj hormone uas pab kom nce siab nyob rau hauv txoj hlab nqaa nqawg taw), uas pab txhawb kev muab nchuav). Cov no suav nrog:
- Azithromycin;
- Clarithromycin;
- Atilmotine;
- Erythromycin.
Cov tshuaj no ua rau kom muaj zog peristaltic. Yog li ntawd, lub plab nws tawm los ntawm kua los yog khoom noj khoom haus. Kuj, lub sij hawm ntawm zaj ntawm cov kab mob hauv plab hnyuv loj txo qis, txawm nyob rau hauv tej yam pathologies, piv txwv li, nrog cov ntshav qab zib gastroparesis lossis cov txheej txheem scleroderma.
Yog tias koj tau raug tso cai rau cov neeg laus cov mob nkeeg rau cov mob pob txha (motilin receptor), yuav tsum xyuam xim vim tias lawv muaj kev phiv. Piv txwv, Erythromycin, npaum li cas rau ntau tshaj ib lub hlis, yuav ua rau kom muaj kev pheej hmoo ntawm kev tuag vim muaj mob plawv txawv txav.