Statins - "rau" thiab "tawm tsam"

Ntau theem ntawm triglycerides thiab cov roj cholesterol hauv cov ntshav yog suav tias yog ib qho xwm txheej txaus ntshai uas tuaj yeem tsim txoj kev loj hlob ntawm cov kab mob plawv. Yuav kom txo cov concentration ntawm cov kev sib txuas lus no yog cov kws kho mob tshwj xeeb, tau kawm ntev. Nws yog ib qho tseem ceeb rau tus neeg mob kom ntsuas txhua yam kev sib ceg ua ntej haus dej haus cawv - thiab tiv thaiv, ua tib zoo saib rau cov kev mob tshwm sim ntawm cov tshuaj no thiab cov kev nyuaj ntawm kev kho mob.

Cov kev pab thiab kev tsim txom ntawm statins rau lub cev

Zus tau muaj cov cholesterol muaj ntau theem dhau los nrog rau kev tsim kho ntawm tus enzyme hu ua mevalonate. Statins cuam tshuam nrog nws cov kev tsim nyob rau ntawm ib theem thaum ntxov thiab, yog li, thaiv cov khoom ntawm triglycerides thiab cov cholesterol.

Thaum kev tshawb nrhiav txog kev kho mob thiab kev sim, nws pom tau tias cov tshuaj nyob rau hauv cov lus nug tau muaj cov teeb meem nram qab no:

1. Txo cov roj cholesterol hauv cov ntshav ntshav (tag nrho - ntawm 35-45%, tsim kev puas tsuaj - los ntawm 45-60%).
2. Txo txoj kev pheej hmoo ntawm cov kab mob ntawm cov hlab plawv, kev tiv thaiv ntawm lub plawv nres, atherosclerosis, cwj nrag, ischemic tawm tsam.
3. Tiv thaiv kev tsim cov cholesterol hauv cov nplooj siab.
4. Ua kom cov concentration ntawm apoliprotein A thiab cov cholesterol tseem ceeb.

Tsis tas li ntawd, kev siv cov statins yog los txhim kho txoj kev noj qab haus huv ntawm cov neeg mob txawm nyob ntawm cov kab mob plawv los ntawm kev txhim kho thiab ntxuav cov phab ntsa hauv cov hlab ntsha. Nyob rau tib lub sijhawm, cov tshuaj no tsis muaj cov kabmob mutagenic thiab carcinogenic.

Dua li ntawm qhov pom tseeb ntawm cov tshuaj uas tau piav, cov kws kho mob tshwj xeeb feem ntau yog cov tsawg thiab tsawg dua cov kws kho mob. Qhov no yog vim muaj qee qhov kev phiv los ntawm kev siv statins:

1. Txo nyob rau theem ntawm tsis tsuas yog teeb meem, tab sis kuj tag nrho cov cholesterol, uas yog tsim nyog rau kev ua hauj lwm ntawm lub cev, tswj kev tuav pov hwm ntawm cov hlab ntsha.
2. Cov teebmeem tsis zoo los ntawm daim siab rau lub siab lub hauv siab rau hauv kev ua kom cov roj ntsha hauv lub cev ua ntej ntawm cov roj ntsha.
3. Rov qab sai dua ntawm kev txhim kho cov roj cholesterol yav tas los ntawm qhov kev tua ntawm cov tshuaj tiv thaiv, uas ua rau lub ntsiav tshuaj noj yuav luag txhua lub neej.

Ntxiv nrog rau cov teeb meem no, muaj ob peb lwm yam kev tsis haum ntawm cov tshuaj.

Cov kev phom sij ntawm cov phom sij

Feem ntau cov phenomena yog:

• asthenic syndrome;
• xeev siab;
• insomnia;
• cem quav;
• mob taub hau;
• flatulence;
• zawv plab;
• ntsuas phoo;
• mob plab;
• migraine;
• kev txaj muag, tsis muaj zog;
• qhov hnoos thiab qhov hnyuv (hypoesthesia);
• kiv taub hau;
• peripheral neuropathy;
• lub sijhawm ntawm amnesia;
• pancreatitis;
• cholestatic jaundice;
• ntuav;
• kab mob siab;
• anorexia;
• kev sib ceg;
• spasms nyob rau hauv cov leeg;
• myositis;
• mob pob txha ntawm pob qij txha;
• myopathy;
• mob hauv sab caj dab;
• exudative erythema;
• pob tawv nqaij ntawm daim tawv nqaij;
• anaphylaxis;
• urticaria thiab khaus;
• Lyell's syndrome ;
• ntshav qab zib mellitus;
• tus kab mob thrombocytopenia;
• hypoglycemia;
• rog;
• peripheral edema.

Ntawm qhov feem ntau txaus ntshai phiv ntawm statins, muaj cov tsos mob siab mob hlwb. Ntau cov kev sim ua tau pom tias feem ntau ntawm cov kev kho mob nrog rau cov tshuaj noj, kev xiam hlwb, kev hais lus, kev paub thiab lub cev ua haujlwm. Qee cov neeg mob txom nyem los ntawm kev mob nkeeg ntawm amnesia, thaum ib tus neeg tsis tuaj yeem tsim cov cim kawg.

Yog li, noj statins yog tsim nyog tsuas yog nyob rau hauv ntau zaus:

1. Ischemic kab mob nrog rau kev pheej hmoo siab ntawm kev mob stroke los yog lub plawv nres.
2. Txoj kev kho kab mob khees xaws (coronary syndrome).
3. Kev phais kho kom zoo dua rau ntawm cov hlab ntsha lossis lub plawv.