Koj puas tau xav txog tias yog vim li cas cov tshuaj siv nrog tib qho kev hloov ua ke feem ntau muaj cov nqi sib txawv? Qhov nrov Imodium yog qhov tseem ceeb tshaj Loperamide, thiab tom qab tag nrho cov tshuaj no ua kom zoo li qub, lawv muaj ib yam khoom ua si. Cov kev qhia rau Loperamide siv yuav zoo li qub, thiab nws cov nqi yuav zoo siab rau koj. Tus mos txwv yog dab tsi?
Ntaus ntawm Loperamide Hydrolochromide
Nyob rau hauv qhov muaj pes tsawg leeg ntawm Imodium thiab Loperamide, tsuas yog ib qho yog Loperamide hydrochloride, qhov kev siv rau kev siv yog raws li nram no:
- mob raws plab ;
- mob raws plab;
- normalization ntawm plab hnyuv me me tom qab phais mob.
Cov kev qhia li no ntawm Loperamide yog vim qhov tseeb tias cov khoom muaj cov nyhuv rau ntawm cov nqaij ntshiv ntawm cov hnyuv thiab vim qhov no qhov quav retention tshwm sim. Loperamide hais txog kev npaj tshuaj opioid thiab yog ib qho kev sib kis ntawm piperidine. Nws ua rau qhov kev txiav txim siab ntawm cov neeg tuaj yeem rau cov hnyuv uas ua rau lub cev tsis zoo thiab ua rau lub siab ua haujlwm rau daim ntawv cog lus, thiab lub tshuab ua haujlwm kom khov. Pib, cov tshuaj tau siv los kho cov mob plab hnyuv thiab ntau hom kev mob ntawm cov hnyuv, hnub no nws yog siv los tiv thaiv kev mob plab.
Loperamide tau pom los ntawm Belgian cov kws tshawb fawb hauv xyoo 1969 thiab txij thaum ntawd los tau nce qib hauv kev ua lag luam nyob rau hauv lub npe Imodium. Nyob rau hauv parallel, nyob rau hauv ntau lub teb chaws, analogues ntawm ib tug yeeb tshuaj nrog sib xws muaj pes tsawg leeg tau tso tawm. Nyob rau hauv Loperamida-Akri cov lus tseem ceeb tib yam rau daim ntawv thov. Tab sis tseem qee yam ntawm cov yeeb tshuaj no sib txawv, namely - cov degree ntawm purification ntawm cov khoom nquag, theem ntawm kev tswj nyob rau hauv qhuav thiab cov nyob rau ntawm cov kev tshawb fawb tshiab ntawm cov khoom. Qhov no yog cov zajlus, vim hais tias ntau ntau lawm, qhov nyiaj ntau nws muaj peev xwm faib rau cov lus nug zoo li no.
Piv txwv li, thaum xyoo 1990, Johnson thiab Johnson, uas yog tam sim no txhawb rau Imodium, thau cov tshuaj ntawm lub lag luam vim ntau tus neeg tuag nyob hauv Pakistan. Tom qab ntawd los ntawm kev siv Imodium, 19 cov menyuam raug kev txom nyem. Cov kev tshawb fawb tseem ceeb ntawm loperamide ntawm qhov no tsis xaus thiab qhov kev kho mob tau kho dua. Qhov tseeb yog tias hauv cov menyuam yaus thiab, xws li, cov me nyuam, piperidine thiab nws cov dej caw ua rau lub siab ntawm cov leeg ntawm cov hnyuv tuaj yeem tuag tes tuag taw. Raws li txoj cai, qhov txiaj ntsig tau pom zoo rau cov me nyuam uas muaj 2 xyoos rov hauv, nyob rau cov laus dua xws li kev ua txhaum cai tsis tshwm sim. Thiab, txawm li cas los, kev siv tshuaj, nrog rau cov loperamide, nyob hauv ntau lub teb chaws tsuas pub cov menyuam yaus tshaj 6 xyoo, thiab hauv Australia, cov menyuam yaus hnub nyoog tshaj 12 xyoos.
Noj tshuaj thiab tswj hwm ntawm Loperamide
Rau cov kev kho mob ntawm tus mob plab, cov neeg laus tau txhaj thawj koob tshuaj Loperamide rau ntawm 4 mg, uas muaj raws li 2 tshuaj ntsiav tshuaj. Nyob rau yav tom ntej, siv 2 mg ntawm cov tshuaj tom qab txhua tus quav, yog tias nws tseem me me, kua. Yog tias cov quav yog qhov qub, lossis tus neeg mob tau cem quav , kev siv cov Loperamide ntsiav tshuaj yuav tsum tsis ua ntxiv lawm.
Rau kev kho mob ntawm kev mob raws plab, cov neeg laus tau sau 2 mg ntawm kev siv tshuaj 1-2 zaug ib hnub kom txog thaum tus mob stabilized.
Cov menyuam yaus hnub nyoog tshaj 6 xyoo raug xaiv ib tus zuj zus thiab yog nce raws li qhov hnyav ntawm tus menyuam lub cev. Txoj kev kho
Qhov ntau hnub ntawm Loperamide rau cov neeg laus yog 16 mg, rau cov menyuam yaus 6-8 mg.
Nyob hauv txoj kev kho mob ntawm lub npe "neeg mob plab", kev mob raws plab thiab tshee hnyuv, cov tshuaj yog ua raws li cov txheej txheem zoo sib xws rau kev kho mob ntawm tus mob plab.
Nrog kev saib xyuas, Loperamide yog ua rau kev ua txhaum ntawm daim siab thiab lub raum. Cov tshuaj yog contraindicated:
- xeeb tub;
- cov niam tsev laus;
- cov menyuam yaus txog 6 xyoo.