Qhov zoo tshaj ntawm qog nqaij hlav necrosis yog hu ua extracellular multifunctional protein, uas yog tsim los ntawm cov kab mob hauv immunocompetent (macrophages, eosinophils). Yog tias ua rau lwm cov hlwb hauv lub cev, cov protein no ua rau cov teebmeem nram qab no:
- acceleration ntawm metabolism hauv lipid;
- pauv hauv cov permeability ntawm cov phab ntsa hauv cov hlab ntsha;
- ntau ntxiv ntawm interleukins (1, 6, 8);
- kev tiv thaiv los ntawm cov kab mob intracellular parasites;
- cov kev cai ntawm cov tshuaj tua kab mob antibody;
- antitumor siv.
Kev kuaj ntshav rau cov qog nqaij hlav necrosis
Txij thaum qog nqaij hlav necrosis yuav siv qhov yuav luag txhua lub cev tiv thaiv kab mob hauv lub cev, nws cov concentration hauv cov ntshav yog txiav txim siab los ntawm qhov kev siv ntawm cov txheej txheem inflammatory. Yog tias kev kuaj ntshav qhia tias qog nqaij hlav necrosis zoo siab, ces qhov no yuav qhia tau xws li pathologies:
- kis kab mob loj heev (kab mob siab C, tus kab mob herpes, endocarditis, etc.);
- sepsis ;
- hnyav mob;
- ischemic plawv;
- psoriasis;
- oncological kab mob;
- cov tshuaj tiv thaiv ntawm cov tshuaj tua kab mob;
- atherosclerosis ntawm cov hlab ntsha ntawm lub plawv thiab lub hlwb;
- ntev bronchopulmonary pathologies;
- autoimmune kab mob ;
- allergic kab mob, thiab lwm yam.
Cov mob qog necrosis hauv keeb
Txiav txim xyuas seb tus nqi qog necrosis zoo li cas yog qhov tseem ceeb hauv kev soj ntsuam txog kev mob qog nqaij hlav. Nrog rau cov qog hlwb, cov protein no qhia txog kev ua si, uas yog qhia hauv hemorrhagic necrosis ntawm malignant neoplastic hlwb tsis ua kev puas tsuaj hlwb. Raws li cov qog nqaij hlav necrosis cais nyob rau hauv ib txoj hauv kev tshwj xeeb los ntawm cov ntshav pub dawb, tshuaj yeeb nrog cov tshuaj tiv thaiv antithumor uas ua tau zoo, ua rau muaj kev cuam tshuam tsawg heev hauv lub cev. Piv txwv, nrog kev pab los ntawm kev siv tshuaj yeeb Kev kho mob cancer mis yog kho.