Vim li cas lub cev yuav tsum tau GSBG?
Nyob rau hauv tib neeg lub cev, testosterone circulates, feem ntau yog nyob rau hauv ib daim ntawv, nrog GHPS, tsawg zaus, nrog albumin. Zoo sib xws li kev hloov ntawm SHBG cuam tshuam txog cov concentration ntawm testosterone hauv cov ntshav.
Cov theem ntawm cov synthesis, ncaj qha SHGG, nyob ntawm cov concentration kev sib deev hormones. Yog li, ua rau cov tshuaj qib qis ntau dua nws cov synthesis. Yog li ntawd, cov ntsiab lus ntawm no hormone nyob rau hauv cov ntshav ntawm cov poj niam yog ob zaug li siab raws li ntawm cov txiv neej. Ua ke nrog cov txo qis rau estradiol, cov ntsiab lus ntawm SHBG hauv cov ntshav ntawm cov poj niam txo.
Cov ntsiab lus ntawm SHBG txiav txim siab hauv cov poj niam yog li cas?
Qee lub sij hawm cov poj niam uas raug txheeb xyuas rau SHGG paub tias nws yog dab tsi, thiab yuav ua li cas thiaj li ua rau nws xav tau - tsis muaj lub tswv yim. Ua ntej tshaj, nws yog qhov tsim nyog yuav tsum paub seb qhov theem ntawm SHBG yuav tsum muaj dab tsi hauv cov poj niam. Nws yuav tsum tam sim ntawd muab sau tias nws cov concentration hauv cov ntshav tsis ruaj khov, thiab nyob ntawm ntau yam. Nws nce los yog tsawg dua yuav tsum tau sau tseg hauv kev mob ntsws.
Cov kev hloov hauv theem ntawm cov tshuaj hormone no yog pom muaj hnub nyoog nce. Yog li, nyob rau hauv cov poj niam:
- 8-10 xyoo - 26-128 nmol / l;
- 10-12 - 16-112 nmol / l;
- 12-14 xyoos - 19-89 nmol / l;
- 14-60 xyoo - 18-114 nmol / l.
Kuj tseem ceeb rau kev kuaj mob ntawm cov kab mob uas feem ntau siv, qhov hu ua IST (kuaj dawb testosterone). Nws yog qhia hauv qhov piv ntawm tag nrho cov testosterone hauv tib neeg lub cev mus rau SHGG. Yog li, hauv cov poj niam qhov kev ntsuas no nws txawv ntawm 0.8-11%, rau txiv neej nws yog 14.8% 95.
Vim li cas cov theem ntawm SHBG nyob rau hauv cov ntshav ntawm cov poj niam yuav nce?
Feem ntau muaj qhov phenomenon qhov twg qib ntawm SHBG rau cov poj niam hauv cov ntshav nce. Ua ntej tshaj, nws tuaj yeem tshwm sim los ntawm:
- kev nce hauv cov ntsiab lus ntawm estrogens hauv cov ntshav ntawm ib tug poj niam;
- hyperthyroid tus mob - pom nyob rau hauv cov pathology ntawm cov thyroid caj pas;
- kab mob siab;
- HIV kis kab mob;
- txais tos ntawm hormonal contraceptives, feem ntau ntawm cov uas muaj estrogens.
Vim li cas qhov txo qis qis ntawm SHBG hauv cov ntshav?
Cov mob no thaum SHBG rau cov poj niam qis dua, lawv hais txog txoj kev loj hlob ntawm cov kab mob pathology. Feem ntau qhov no yog:
- nephrotic syndrome (kev cuam tshuam ntawm qhov kev tsim tawm);
- nce qib ntawm androgens nyob rau hauv cov ntshav - hyperadromia ;
- ntshav qab zib mellitus ;
- acromegaly;
- Cushing tus kab mob;
- nce prolactin theem hauv cov ntshav;
- polycystic syndrome ntawm zes qe menyuam;
- cirrhosis ntawm lub siab;
- cov tshuaj, xws li: Danazol, Somatostatin, thiab cov tshuaj muaj sia thiab muaj tshuaj ntsuab thiab glucocorticoids.
Yuav ua li cas los tswj cov theem ntawm SHBG?
Yuav kom txiav txim siab txog qib ntawm SHBG rau hauv lub cev ntawm ib tug poj niam, ntshav sampling yog nqa tawm. Cov hauv qab no yuav tsum tau pom zoo:
Qhov ntsuam yog nqa tawm ntawm ib qho kev npliag plab, thaum sawv ntxov. - 72 xuab moos ua ntej txoj kev kho mob, nws yuav tsum tshem tawm qhov kom tag nrho cov tshuaj hormonal.
- Txwv tsis pub dhau kev sib deev.
Feem ntau ntawm qhov kev ntsuam xyuas yog twb paub tom qab ib hnub. Nyob rau tib lub sij hawm, nws txoj kev hais tawm yuav tsum raug tshwj tawm los ntawm ib tug kws kho mob. Yog li, paub txog tias qhov no yog SHGG, thiab rau qhov nws ua tiav, tus poj niam yuav tsum tsis txhob poob siab tom qab tau txais qhov kev ntsuam xyuas, thiab tsis muaj qhov teeb meem nws yuav ua qhov kev txiav txim siab ywj siab, tab sis nws yeej yuav nrhiav tswv yim los ntawm ib tus kws kho mob pojniam.