Bisphosphonate npaj

Ib chav tshwj xeeb ntawm cov tshuaj uas tiv thaiv pob txha thiab nws qhov kev puas tsuaj los ntawm osteoclasts yog nquag siv rau hauv kev kho mob ntawm cov kab mob hauv cov poj niam. Bisphosphonate los yog dysphosphonate preparations yog cov khoom sib txuas ua ke uas zoo sib xws ua rau ntuj pyrophosphates resistant rau resorption. Hnub no lawv suav hais tias tsuas yog cov tshuaj noj rau hauv kev ua haujlwm nrog kev ua haujlwm zoo.

Cov npe ntawm kev npaj ntawm bisphosphonate pab pawg

Hom tshuaj uas xam tau tias yog muab cais ua 2 pawg loj - cov tshuaj muaj nitrogen thiab tshuaj tsis muaj nws.

Thawj ntau yam muaj xws li:

1. Alendronic acid. Txoj kev xav txhawb kev kho kom zoo dua qub thiab tsim kom muaj qhov tseeb cov qauv ntawm cov pob txha, tswj cov kev pauv thiab kev ua haujlwm tsis tu ncua. Nws yog feem ntau tau hais rau cov menyuam yaus thiab tom qab menopausal osteoporosis, malignant hypercalcemia thiab deforming osteitis, los tiv thaiv kom txhob muaj pob txha;
2. Zolendronate lossis zoledronic acid. Suppresses cov kev ua ntawm osteoclasts, tab sis tsis cuam tshuam rau cov txheej txheem ntawm pob txha mineralization, mechanical zog thiab cov nqaij mos;
3. Clodronic acid (Clodron, Bonefos). Txo txoj kev pheej hmoo ntawm pob txha ntawm cov pob txha, ua rau muaj cov tshuaj loog. Nws yog siv hauv kev sim tshuaj, xaiv cov kev puas tsuaj ntawm cov kab mob pathological;
4. Bondronate (ibadronic acid). Tsim tshwj xeeb rau kev kho cov poj niam, tshwj xeeb tshaj yog cov ntsiab lus nyob rau hauv lub sij hawm climacteric. Kuj siv thaum lub sijhawm hormonal hloov kho.

Bezazotistye bisphosphonates tau noj nrog metastases hauv cov pob txha, cov ntaub ntawv ntawm cov hlav malignant, hypercalcemia. Hauv qhov no, qhov kev xaiv kom yog qhov tseeb, uas tus kws kho mob yuav tsum xam. Txwv tsis pub, tshwj xeeb tshaj yog nrog ib qho overdose, muaj teeb meem tshwm sim.

Sau ntawm bisphosphonate npaj tsis muaj nitrogen:

1. Tiludronate. Tsub kom mob qhov nqaij ntawm cov pob txha, yog li feem ntau nws tau sau thaum muaj deformities thiab pob txha;
2. Xidiphon, Pleistat los yog sodium etidronate. Nws yog dav siv nyob rau hauv txoj kev kho ntawm Paget tus kab mob, oncological kab mob, hypercalcemia, loj heev osteoporosis;
3. Ibandronate sodium. Nws yuav pab kom zoo nrog cov tshuaj hormonal rau kev hloov kho hauv cov menopausal tom qab;
4. Clodronate. Tiv thaiv kev puas tsuaj ntawm calcium uas muaju, qhov kev loj hlob ntawm osteolysis. Cov tshuaj muaj npe rau cov hlab ntsha qog nqaij hlav, leukemias, lymphomas, metastases loj heev.

Kev qhia rau bisphosphonates

Kev lees txais ntawm cov tshuaj uas tau piav saum toj no yog ua tiav raws li tus kws kho mob pom zoo 1 zaug hauv ib hnub.

Bisphosphonates yog cov tsis tshua muaj soluble, yog li lawv yuav tsum tau muab ntxuav nrog cov dej ntshiab tsis tshua muaj kev kub ntawm chav tsev kub kom zoo tshaj qhov nqus.

Nws yog ntshaw mus soj ntsuam ib qho kev ncua ntawm kev nkag khoom noj khoom haus thiab kab mob ntses. Ntsiav tshuaj yuav tsum tau noj li 1,5 teev ua ntej noj mov ntawm lub plab tas - tsis pub dhau 60 feeb tom qab noj mov.

Ib qho ntawm cov tsis txaus siab ntawm no pab pawg neeg ntawm cov yeeb tshuaj yog lawv muaj peev xwm mus irrit mucosa ntawm esophagus, mus provoke tsim ntawm me me ulcers on nws saum npoo. Yog li, tom qab noj bacterialphonates koj mus tsis tau mus pw tam sim ntawd, nws yog qhov tseem ceeb rau 90 feeb (yam tsawg) yuav tsum nyob rau hauv ib txoj hauj lwm upright, koj yuav tau zaum, tab sis nws tseem zoo dua mus taug kev ntawm ko taw los yog cia li ua hauv tsev. Qhov no yuav tiv thaiv tej kev mob tshwm sim xws li kev kub ntxhov , qhov rov qab reflux thiab es mob plab.